湖北蝶化新材料科技有限公司
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产品名称： L-墨蝶呤 Cas No.： 17094-01-8 分子式： C9H11N5O3 分子量： 237.22 中文名称L-墨蝶呤中文同义词S-(-)-2-氨基-7,8-二氢-6-(2-羟基-1-氧代丙基)-4(1H)-蝶啶酮;墨蝶呤;L-墨蝶呤;乌贼乙素(L-乌贼乙素);墨蝶蛉(L-墨蝶蛉);(S)-2-氨基-6-(2-羟基丙酰基)-7,8-二氢蝶啶-4(3H)-酮英文名称L-SEPIAPTERIN英文同义词(S)-2-aMino-6-(2-hydroxypropanoyl)-7,8-dihydropteridin-4(1H)-one;(S)-2-AMino-6-(2-hydroxypropanoyl)-7,8-dihydropteridin-4(3H)-one;Sepiapterinsolid;S(-)-2-AMINO-7,8-DIHYDRO-6-(2-HYDROXY-1-OXOPROPYL)-4(1H)-PTERIDINONE;SEPIAPTERIN;L-SEPIAPTERIN;L-SEPIAPTERINDIHYDRATE;2-AMINO-7,8-DIHYDRO-6-(2S-HYDROXY-1-OXOPROPYL)-4(1H)-PTERIDINONECAS号17094-01-8分子式C9H11N5O3分子量237.22EINECS号相关类别对照品Mol文件17094-01-8.mol结构式L-墨蝶呤性质熔点>270°C(dec.)沸点448.1±55.0°C(Predicted)密度1.86±0.1g/cm3(Predicted)储存条件-20°C溶解度二甲基亚砜：27毫克/毫升酸度系数(pKa)12.33±0.20(Predicted)形态固体颜色粘黄色稳定性感光CAS数据库17094-01-8L-墨蝶呤用途与合成方法生物活性L-Sepiapterin(Sepiapterin)是内皮型一氧化氮合酶(eNOS)辅因子四氢生物喋呤(BH4)的前体。L-Sepiapterin改善db/db小鼠肠系膜小动脉内皮功能障碍，诱导血管生成Chemicalbook。L-Sepiapterin通过下调p70S6K依赖性VEGFR-2表达抑制卵巢癌细胞增殖和迁移。靶点HumanEndogenousMetabolite体外研究L-Sepiapterin(Sepiapterin)(0.1-10μM;24hpurs)Iinducescellproliferationinadose-dependentmanner.L-Sepiapterin(1-50μM;20minutes)significantlyinhibitsthephosphorylationofVEGF-A-induced(50ng/ml)p70S6K.L-SepiapterininhibitsVEGF-A-inducedcellproliferationandmigrationthroughNO-independentmechanism.CellProliferationAssayCellLine:SKOV-3cellsConcentration:0.1,1,10μMIncubationTime:24hoursResult:Inducedcellproliferationinadose-dependentmanner.体内研究Sepiapterin(10mg/kg;p.o.(powderchow);dailyforor8weeks)significantlyimprovestherelaxationtoAchinsmallmesentericarteries(SMA)fromdb/dbmice.AnimalModel:MaleC57BL/KsJdiabeticmice(db/db)Dosage:10mg/kgAdministration:P.o.(powderchow);dailyforor8weeksResult:SignificantlyimprovedtherelaxationtoAchinSMAfromdb/dbmice.