湖北蝶化新材料科技有限公司
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产品名称： HOECHST 34580 Cas No.： 23555-00-2 分子式： 分子量： 中文名称HOECHST34580中文同义词赫斯特34580游离;N,N-二甲基-4-(5-(4-甲基哌嗪-1-基)-1H,1’H-[2,5’-联苯并[D]咪唑]-2’-基)苯胺;化合物HOECHST34580;NO34580荧光染料;N,N-二甲基-4-(5-(4-甲基哌嗪-1-基)-1H,1’H-[2,5’-联苯并[D]咪唑]-2’-基)苯胺英文名称HOECHST34580英文同义词HOECHST34580;HOE34580;ProaMine;2,50-bibenzimidazole,20-[p-(dimethylamino)phenyl]-5-(4-methyl-1-piperazinyl)-;Benzenamine,N,N-dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5’-bi-1H-benzimidazol]-2’-yl]-;Hoechst34580(HOE34580);N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1’H-[2,5’-bibenzo[d]imidazol]-2’-yl)aniline;N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1’H-[2,5’-bibenzo[d]imidazol]-2’-yl)anilineCAS号23555-00-2分子式C27H29N7分子量451.57EINECS号相关类别BenzimidazoleMol文件23555-00-2.mol结构式HOECHST34580性质熔点>300℃沸点733.2±70.0°C(Predicted)密度1.280±0.06g/cm3(Predicted)储存条件2-8°C(protectfromlight)溶解度溶于二甲亚砜、水酸度系数(pKa)10.97±0.10,mostacidic,temperature:25°C;7.66±0.42,mostbasic(at25℃)形态Chemicalbook粉末颜色黄色到绿色最大波长(λmax)392nm生物领域应用Detectingmalariainfectedredbloodcells,polynucleotides;nucleicacidamplification;nucleicacidsequencingHOECHST34580用途与合成方法生物活性Hoechst34580(HOE34580)是一种具有细胞渗透性的蓝色荧光染料，用于染色DNA和细胞核。Hoechst34580也是一种治疗阿尔茨海默病的良好候选者，通过抑制amyloidbeta(Aβ)的形成，其IC50值为0.86μM。靶点TargetValueAβ(Cell-freeassay)0.86μM体外研究Hoechst34580preferstolocatenearhydrophobicregionswithbindingaffinitywiththeinhibitionconstantIC50of0.86±0.05μMforHoechst34580.Hoechst34580isagoodcandidatefortreatingtheAlzheimer’sdiseasebyinhibitingAβformation.50μMAβ42solutionsco-incubatedwith100,25,12.5,3.125,0.78,and0.1,0.01μMHoechst34580at37°Cfor70h.Hoechst34580caninhibittheaggregationofAβ42inadose-dependentmanner.Andthehalf-maximalconcentration(IC50)isexamined.TheIC50isobtainedbymeasuringtheconcentrationofHoechst34580whilemaintainingtheAβ42concentrationwhichgave0.86±0.05μMforHoechst34580.